I view science as a social construct essential for enhancing and promoting the health and well-being of individuals.
Full profile: Otavio Ranzani
Interests
- Critical Care
- Environment
- Methods
- Respiratory Infections
Education
PhD in Epidemiology, 2018
University of São Paulo, Brazil
MSc in Epidemiology, 2014
London School of Hygiene & Tropical Medicine (LSHTM)
MD in Medicine, 2008
University of São Paulo, Brazil
Latest
- Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in São Paulo, Brazil: a test-negative, case–control study
- Using the Observational Medical Outcomes Partnership Common Data Model for a multi-registry intensive care unit benchmarking federated analysis: lessons learned
- Allostatic overload as the pathophysiological basis for integrating palliative care in the Intensive Care Unit
- Telemedicine in critical care
- Nosocomial lower respiratory tract infections in patients with immunosuppression: a cohort study
- Peri-intubation adverse events and clinical outcomes in emergency department patients: the BARCO study
- Identification and validation of robust hospital-acquired pneumonia subphenotypes associated with all-cause mortality: a multi-cohort derivation and validation
- TB as a risk factor for severe COVID-19 mortality
- Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study
- Ambient temperature and dengue hospitalization in Brazil: A 10-year period case time series analysis
- Factors Associated with Mortality in Nosocomial Lower Respiratory Tract Infections: An ENIRRI Analysis
- Common pitfalls in critical care research
- Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia
- Prenatal exposure to ambient air pollution and subsequent risk of lower respiratory tract infections in childhood and adolescence: A systematic review
- The burden, clinical features and outcomes of SARS-CoV-2, Influenza and co-infections during concurrently out-of-season outbreaks in Brazil
- Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients: The TELESCOPE Randomized Clinical Trial
- Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients: The TELESCOPE Randomized Clinical Trial
- Fludrocortisone with hydrocortisone in sepsis: new evidence in an ongoing debate
- D-PRISM: a global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive care
- Environmental Exposures and Long COVID in a Prospective Population-Based Study in Catalonia (COVICAT Study)
- Antibody responses to common viruses according to COVID-19 severity and postacute sequelae of COVID-19
- Prevalence, risk factors, and impact of long COVID in a socially vulnerable community in Brazil: a prospective cohort study
- Severity-dependent test-seeking behaviors and test-negative designs: impact on estimated vaccine effectiveness and utility of analytic and design choices
- #VacinaMare campaign: addressing vaccine inequity in socially vulnerabilised communities
- Impact of the first year of COVID-19 vaccination strategy in Brazil: an ecological study
- Effectiveness of COVID-19 vaccines against severe COVID-19 among patients with cancer in Catalonia, Spain
- Effectiveness of the fourth dose of COVID-19 vaccines against severe COVID-19 among adults 40 years or older in Brazil: a population-based cohort study
- The Association Between Prepandemic ICU Performance and Mortality Variation in COVID-19: A Multicenter Cohort Study of 35,619 Critically Ill Patients
- Who is more vulnerable to effects of long-term exposure to air pollution on COVID-19 hospitalisation?
- Short-term exposure to air pollution and hospital admission after COVID-19 in Catalonia: the COVAIR-CAT study
- Long-term outcomes for epidemic viral pneumonia survivors after discharge from the intensive care unit: a systematic review
- Closing the critical care knowledge gap: the importance of publications from low-income and middle-income countries
- Diagnosis and management of autoimmune diseases in the ICU
- Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in children under 5 years
- European Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial LRTI
- Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations
- Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations
- Vaccine coverage and effectiveness against laboratory-confirmed symptomatic and severe Covid-19 in indigenous people in Brazil: a cohort study
- Long-term exposure to air pollution and severe COVID-19 in Catalonia: a population-based cohort study
- Long-term exposure to air pollution and severe COVID-19 in Catalonia: a population-based cohort study
- Effect of walnut consumption on neuropsychological development in healthy adolescents: a multi-school randomised controlled trial
- Effectiveness of a multicomponent intervention to face the COVID-19 pandemic in Rio de Janeiro's favelas: difference-in-differences analysis
- Management of diabetic ketoacidosis
- What we talk about when we talk about COVID-19 vaccination campaign impact: a narrative review
- Determination of Anti-Phospholipase A2 and Anti-Thrombospondin Type 1 Domain-Containing Protein 7A in Latin Patients with Membranous Nephropathy
- Association between primary or booster COVID-19 mRNA vaccination and Omicron lineage BA.1 SARS-CoV-2 infection in people with a prior SARS-CoV-2 infection: A test-negative case-control analysis
- Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
- Characteristics and outcomes of autologous hematopoietic stem cell transplant recipients admitted to intensive care units: A multicenter study
- Optimising aerosolized therapies in critically ill patients
- Primary healthcare protects vulnerable populations from inequity in COVID-19 vaccination: An ecological analysis of nationwide data from Brazil
- The importance for tuberculosis of mitigating economic crises
- Ventilator-associated pneumonia
- Lessons From the COVID-19 Pandemic in Latin America: Vulnerability Leading to More Vulnerability
- Mental health morbidity, self-harm, and suicide in ICU survivors and caregivers
- Urban-rural differences in hypertension prevalence in low-income and middle-income countries, 1990-2020: A systematic review and meta-analysis
- Vaccine effectiveness of ChAdOx1 nCoV-19 against COVID-19 in a socially vulnerable community in Rio de Janeiro, Brazil: author's response
- Association of ambient and household air pollution with lung function in young adults in an peri-urban area of South-India: A cross-sectional study
- Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals
- Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline
- Use of Recently Vaccinated Individuals to Detect Bias in Test-Negative Case-Control Studies of COVID-19 Vaccine Effectiveness
- Change in covid-19 risk over time following vaccination with CoronaVac: test negative case-control study
- Effectiveness of CoronaVac, ChAdOx1 nCoV-19, BNT162b2, and Ad26.COV2.S among individuals with previous SARS-CoV-2 infection in Brazil: a test-negative, case-control study
- One Health and surveillance of zoonotic tuberculosis in selected low-income, middle-income and high-income countries: A systematic review
- Phrenic Nerve Block and Respiratory Effort in Pigs and Critically Ill Patients with Acute Lung Injury
- Vaccine effectiveness of ChAdOx1 nCoV-19 against COVID-19 in a socially vulnerable community in Rio de Janeiro, Brazil: a test-negative design study
- Booster doses for inactivated COVID-19 vaccines: if, when, and for whom
- Prediction of ventilator-associated pneumonia outcomes according to the early microbiological response: a retrospective observational study
- Seroepidemiology of SARS-CoV-2 on a partially vaccinated island in Brazil: Determinants of infection and vaccine response
- Effectiveness of ChAdOx1 vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo
- Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study
- Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil
- Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil: test negative case-control study
- COVID-19 hospital admissions: Brazil's first and second waves compared
- Recovery after prolonged ICU treatment in patients with COVID-19
- Community-acquired pneumonia severity assessment tools in patients hospitalized with COVID-19: a validation and clinical applicability study
- Impact of Cardiovascular Failure in Intensive CareUnit-Acquired Pneumonia: A Single-Center, Prospective Study
- TELE-critical Care verSus usual Care On ICU PErformance (TELESCOPE): protocol for a cluster-randomised clinical trial on adult general ICUs in Brazil
- Characterisation of the first 250,000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data
- Impact of nonclinical factors on intensive care unit admission decisions: a vignette-based randomized trial (V-TRIAGE)
- Increasing tuberculosis burden in Latin America: an alarming trend for global control efforts
- Validation of a Prediction Score for Drug-Resistant Microorganisms in Community-acquired Pneumonia
- Association between ambient temperature and heat waves with mortality in South Asia: Systematic review and meta-analysis
- Defining pathways to healthy sustainable urban development
- Noninvasive ventilation in critically ill very old patients with pneumonia: A multicenter retrospective cohort study
- Walnuts, Long-Chain Polyunsaturated Fatty Acids, and Adolescent Brain Development: Protocol for the Walnuts Smart Snack Dietary Intervention Trial
- Pulmonary infections complicating ARDS
- Diagnostic accuracy of Gram staining when predicting staphylococcal hospital-acquired pneumonia and ventilator-associated pneumonia: a systematic review and meta-analysis
- Association between sepsis at ICU admission and mortality in patients with ICU-acquired pneumonia: An infectious second-hit model
- Physical and mental health effects of repeated short walks in a blue space environment: A randomised crossover study
- Association of Sepsis Diagnosis at Daytime and on Weekdays with Compliance with the 3-Hour Sepsis Treatment Bundles. A Multicenter Cohort Study
- Focus on better care and ethics: Are medical ethics lagging behind the development of new medical technologies?
- Diagnosis of ventilator-associated pneumonia in critically ill adult patients-a systematic review and meta-analysis
- Personal exposure to particulate air pollution and vascular damage in peri-urban South India
- Progression of confirmed COVID-19 cases after the implementation of control measures
- Focus on the frail and elderly: who should have a trial of ICU treatment?
- Land-Use Change and Cardiometabolic Risk Factors in an Urbanizing Area of South India: A Population-Based Cohort Study
- Potential for Life Course Health Benefits From Improved Household Environments
- Association of Ambient and Household Air Pollution With Bone Mineral Content Among Adults in Peri-urban South India
- Selected oncological patients may even restart cancer treatment after in-hospital cardiac arrest
- Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project
- Characterisation of the first 250,000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data
- Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010-15: a population-based, longitudinal study
- Association of Ambient and Household Air Pollution With Bone Mineral Content Among Adults in Peri-urban South India
- Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010-15: a population-based, longitudinal study
- Lack of association between particulate air pollution and blood glucose levels and diabetic status in peri-urban India
- Biomarkers in community-acquired pneumonia: can we do better by using them correctly?
- Ambient Particulate Air Pollution and Blood Pressure in Peri-urban India
- Hippocampal Damage During Mechanical Ventilation in Trendelenburg Position: A Secondary Analysis of an Experimental Study on the Prevention of Ventilator-Associated Pneumonia
- Lymphocytopenia as a Predictor of Mortality in Patients with ICU-Acquired Pneumonia
- A decision-aid tool for ICU admission triage is associated with a reduction in potentially inappropriate intensive care unit admissions
- Nebulized Amikacin and Fosfomycin for Severe Pseudomonas aeruginosa Pneumonia: An Experimental Study
- Effect of Combined β-Lactam/Macrolide Therapy on Mortality According to the Microbial Etiology and Inflammatory Status of Patients With Community-Acquired Pneumonia
- Invasive and non-invasive diagnostic approaches for microbiological diagnosis of hospital-acquired pneumonia
- Recruitment manoeuvres dislodge mucus towards the distal airways in an experimental model of severe pneumonia
- Zoonotic Tuberculosis in Humans: Control, Surveillance, and the One Health Approach
- A Comparison of Mortality From Sepsis in Brazil and England: The Impact of Heterogeneity in General and Sepsis-Specific Patient Characteristics
- In-vitro analysis of a novel 'add-on' silicone cuff to improve sealing properties of tracheal tubes
- Appraisal of systemic inflammation and diagnostic markers in a porcine model of VAP: secondary analysis from a study on novel preventive strategies
- Diagnosis of nonventilated hospital-acquired pneumonia: how much do we know?
- Is occupational biomass smoke exposure an overlooked driver of respiratory health?
- Prompt admission to the ICU: an instrument to improve mortality for deteriorating ward patients
- Severity scoring systems for pneumonia: current understanding and next steps
- Who are the patients with tuberculosis who are diagnosed in emergency facilities? An analysis of treatment outcomes in the state of São Paulo, Brazil
- Evaluation of the 2016 Infectious Diseases Society of America/American Thoracic Society Guideline Criteria for Risk of Multidrug-Resistant Pathogens in Patients with Hospital-acquired and Ventilator-associated Pneumonia in the ICU
- Reply to Akinosoglou and Gogos: Sepsis-3 in Community-acquired Pneumonia: How Reliable Is It?
- Rio's Mountainous Region ("Região Serrana") 2011 Landslides: Impact on Public Mental Health System
- Severe community-acquired pneumonia: Characteristics and prognostic factors in ventilated and non-ventilated patients
- Is this critically ill patient elderly or too old?
- New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality. A Validation and Clinical Decision-Making Study
- Randomized, multicenter trial of lateral Trendelenburg versus semirecumbent body position for the prevention of ventilator-associated pneumonia
- Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project
- The Epimed Monitor ICU Database®: a cloud-based national registry for adult intensive care unit patients in Brazil
- Diagnostic Value of Endotracheal Aspirates Sonication on Ventilator-Associated Pneumonia Microbiologic Diagnosis
- Focus on immunocompromised patients
- Respiratory research networks in Europe and beyond: aims, achievements and aspirations for the 21st century
- Rapid identification of antimicrobial resistance patterns allows a faster antibiotic adequacy
- Peripherally inserted central catheters are associated with lower risk of bloodstream infection compared with central venous catheters in paediatric intensive care patients: a propensity-adjusted analysis
- The authors reply
- Comparison of two prognostic scores (BSI and FACED) in a Spanish cohort of adult patients with bronchiectasis and improvement of the FACED predictive capacity for exacerbations
- Estimating the impact of tuberculosis anatomical classification on treatment outcomes: A patient and surveillance perspective analysis
- Treatment with macrolides and glucocorticosteroids in severe community-acquired pneumonia: A post-hoc exploratory analysis of a randomized controlled trial
- Lactated Ringer Is Associated With Reduced Mortality and Less Acute Kidney Injury in Critically Ill Patients: A Retrospective Cohort Analysis
- Pneumonia in 2016: towards better care
- Prone position and VAP incidence in the PROSEVA trial: attention to the causal question when interpreting competing risk analysis
- Chlorhexidine bathing for the prevention of colonization and infection with multidrug-resistant microorganisms in a hematopoietic stem cell transplantation unit over a 9-year period: Impact on chlorhexidine susceptibility
- The Challenge of Predicting Pressure Ulcers in Critically Ill Patients. A Multicenter Cohort Study
- Timing of Initiation of Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury
- There is no cephalocaudal gradient of computed tomography densities or lung behavior in supine patients with acute respiratory distress syndrome
- The value of antibody-coated bacteria in tracheal aspirates for the diagnosis of ventilator-associated pneumonia: a case-control study
- The impact of being homeless on the unsuccessful outcome of treatment of pulmonary TB in São Paulo State, Brazil
- Evaluation of cost-effectiveness from the funding body's point of view of ultrasound-guided central venous catheter insertion compared with the conventional technique
- Protocolized sedation effect on post-ICU posttraumatic stress disorder prevalence: A systematic review and network meta-analysis
- Community-acquired pneumonia
- Community-acquired pneumonia
- Variability in forgoing life-sustaining treatments: reasons and recommendations
- Importance of a registered and structured protocol when conducting systematic reviews: comments about nebulized antibiotics for ventilator-associated pneumonia
- How should I structure my Post-ICU Clinic? From early goal rehabilitation to outpatient visits
- One-year survival and resource use after critical illness: impact of organ failure and residual organ dysfunction in a cohort study in Brazil
- Nebulized antibiotics for ventilator-associated pneumonia: a systematic review and meta-analysis
- Anxiety, depression, and satisfaction in close relatives of patients in an open visiting policy intensive care unit in Brazil
- Hyperoxia following cardiac arrest
- Endotracheal tube biofilm translocation in the lateral Trendelenburg position
- Risk factors associated with potentially antibiotic-resistant pathogens in community-acquired pneumonia
- Emotional disorders in pairs of patients and their family members during and after ICU stay
- EuroSCORE models in a cohort of patients with valvular heart disease and a high prevalence of rheumatic fever submitted to surgical procedures
- Evaluation of a minimal sedation protocol using ICU sedative consumption as a monitoring tool: a quality improvement multicenter project
- Gravity predominates over ventilatory pattern in the prevention of ventilator-associated pneumonia
- Relationship between acid-base status and inflammation in the critically ill
- Nosocomial pneumonia in the intensive care unit: how should treatment failure be predicted?
- A novel porcine model of ventilator-associated pneumonia caused by oropharyngeal challenge with Pseudomonas aeruginosa
- The effects of discharge to an intermediate care unit after a critical illness: a 5-year cohort study
- Recalibrating our prediction models in the ICU: time to move from the abacus to the computer
- Implementation of a multifaceted sepsis education program in an emerging country setting: clinical outcomes and cost-effectiveness in a long-term follow-up study
- An increase in mean platelet volume after admission is associated with higher mortality in critically ill patients
- Extracorporeal membrane oxygenation for severe respiratory failure in adult patients: a systematic review and meta-analysis of current evidence
- How objective is the observed mortality following critical care?
- Highlighting the important effect of systemic lupus erythematosus on platelet count of critically ill patients
- Reclassifying the spectrum of septic patients using lactate: severe sepsis, cryptic shock, vasoplegic shock and dysoxic shock
- Long-term mortality after critical care: what is the starting point?
- ICU-acquired pneumonia with or without etiologic diagnosis: a comparison of outcomes
- Validation of predictors of adverse outcomes in hospital-acquired pneumonia in the ICU
- Anion gap corrected for albumin, phosphate and lactate is a good predictor of strong ion gap in critically ill patients: a nested cohort study
- Blindness: perceptions under mechanical ventilation
- Effect of intraoperative HES 6% 130/0.4 on the need for blood transfusion after major oncologic surgery: a propensity-matched analysis
- C-reactive protein/albumin ratio predicts 90-day mortality of septic patients
- Effects of manual rib cage compressions on expiratory flow and mucus clearance during mechanical ventilation
- Thrombocytosis is a marker of poor outcome in community-acquired pneumonia
- An in vitro study to assess determinant features associated with fluid sealing in the design of endotracheal tube cuffs and exerted tracheal pressures
- C-reactive protein/albumin ratio predicts 90-day mortality of septic patients
- Systematic implementation of evidence-based guidelines in intensive care medicine: resistance to change is human nature
- Failure to reduce C-reactive protein levels more than 25% in the last 24 hours before intensive care unit discharge predicts higher in-hospital mortality: a cohort study
- Association between systemic corticosteroids and outcomes of intensive care unit-acquired pneumonia
- Outcomes and organ dysfunctions of critically ill patients with systemic lupus erythematosus and other systemic rheumatic diseases
- Video-assisted thoracoscopy as an option in the surgical treatment of chylothorax after cardiac surgery in children
- Intraluminal plugs in idiopathic and secondary organizing pneumonia: repair or remodelling?
- Cyclosporin A reduces airway mucus secretion and mucociliary clearance in rats