Clinical Trials & Implementation Science

Rigorous Evidence  ·  Equitable Delivery  ·  Community Partnership

Clinical trials are the backbone of evidence-based medicine, but generating evidence and implementing it are two different disciplines: both equally demanding. Our group works across this entire spectrum: co-designing and contributing to interventional trials as investigators, trialists and statisticians/methodologists, and embedding implementation science to ensure findings reach the populations who need them most.

We bring particular expertise in critical care and infectious disease trials, both national and international, frequently contributing rigorous statistical frameworks including pre-registered protocols and statistical analysis plans (SAPs). In parallel, our community-embedded implementation science addresses the gap between what trials show and what actually happens on the ground. We have acquired special expertise in implementation science, particularly in vulnerabilised settings where standard trial infrastructure is absent and community trust must be earned.

Our Data Safety Monitoring Board (DSMB) work gives us experience and a privileged vantage point across a broad portfolio of trials worldwide, informing decisions that directly affect participant safety and the integrity of the evidence base.

Randomised controlled trials where I contributed as PI, trialist or lead statistician, including traditional and adaptive designs, frequentist and Bayesian frameworks.

Implementation science asks not just what works in trials, but how proven interventions can be delivered equitably at scale, in hospitals and communities that need them most. Our work spans vaccine delivery and infectious disease prevention in vulnerabilised urban settings, and quality improvement in emergency and critical care globally.

We draw on rigorous methodological frameworks, including Hybrid Effectiveness-Implementation Trial Designs and the Consolidated Framework for Implementation Research (CFIR), while embracing innovative and creative approaches that go beyond standard templates: partnering with local organisations, embedding community health workers, co-designing data collection tools with frontline staff, and adapting interventions to resource-constrained realities. We work with communities, clinicians and stakeholders.

Where have we been working?

Countries involved in clinical trials and implementation science work (n = 17).

As an expert, I have contributed to independent DSMBs, either as chair, trialist or statistician. My role is to protect participant safety, guarantee high methodological and ethical standards, review accumulating unblinded data on efficacy and harm, and make independent recommendations to trial steering committees, including decisions to stop, modify, or continue a trial.

🧠 Key Principle

Evidence from clinical trials is only as valuable as its reach. We design studies to answer questions that communities already have, and we build the implementation infrastructure to deliver findings where they matter.